Cui Lab

Publications

Please do not hesitate to contact us for copies of publications!

The Cui lab:

Tijaro-Bulla, S.*, Nyandwi, S.P.*, Cui, H., 2023, Physiological and engineered tRNA aminoacylation, Wiley Interdiscip Rev RNA, e1789.

Elsakrmy, N., Cui, H., 2023, R-Loops and R-Loop-Binding Proteins in Cancer Progression and Drug Resistance, Int. J. Mol. Sci. 2023, 24(8), 7064

Sun, L., Zhou, X.-L., Zhou, Z.-W., and Cui, H. (2023). Editorial: Noncanonical functions of Aminoacyl-tRNA synthetases. Front Physiol 14, 1165515.

Haissi before joining U of Toronto:
As first author:

Postdoc at Scripps Research
Cui, H., Diedrich, J.K., Wu, D.C., Lim, J.J., Nottingham, R.M., Moresco, J.J., Yates, J.R., Blencowe B.J., Lambowitz, A.M., Schimmel, P., 2023, Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2, Nat Cell Biol, 25(4):592-603.
BioRxiv
News and Views

Cui, H., Kapur, M., Diedrich, J.K., Yates III, J.R., Ackerman, S.L., Schimmel, P., 2021. Regulation of Ex-Translational Activities Is the Primary Function of the Multi-tRNA Synthetase Complex, Nucleic Acid Research 49(7), 3603-3616. Breakthrough Article (best 2-3% of articles).
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Scripps Research Press Release
HFSP news and events

Postdoc at Technical University Munich
Cui, H.*, Baur, R.*, Le Chapelain, C., Dubiella, C., Heinemeyer, W., Huber, E.M., Groll, M., 2017. Structural Elucidation of a Nonpeptidic Inhibitor Specific for the Human Immunoproteasome. ChemBioChem 18, 523–526.

Dubiella, C.*, Cui, H.*, Groll, M., 2016. Tunable Probes with Direct Fluorescence Signals for the Constitutive and Immunoproteasome. Angewandte Chemie International Edition 55, 13330–13334.

Beck, P.*, Cui, H.*, Hegemann, J.D., Marahiel, M.A., Krüger, A., Groll, M., 2015. Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation. ChemMedChem 10, 1969–1973.
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PhD at MRI TUM
Cui, H., Seubert, B., Stahl, E., Dietz, H., Reuning, U., Moreno-Leon, L., Ilie, M., Hofman, P., Nagase, H., Mari, B., Krüger, A., 2015. Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes. Oncogene 34, 3640–3650.

Seubert, B.*, Cui, H.*, Simonavicius, N., Honert, K., Schäfer, S., Reuning, U., Heikenwalder, M., Mari, B., Krüger, A., 2015. Tetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization. International Journal of Cancer 136, 2304–2315.
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Seubert, B.*, Grünwald, B.*, Kobuch, J.*, Cui, H.*, Schelter, F., Schaten, S., Siveke, J.T., Lim, N.H., Nagase, H., Simonavicius, N., Heikenwalder, M., Reinheckel, T., Sleeman, J.P., Janssen, K.-P., Knolle, P.A., Krüger, A., 2015. Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. Hepatology. Md 61, 238–248.

Cui, H.*, Grosso, S.*, Schelter, F., Mari, B.*, Krüger, A.*, 2012. On the Pro-Metastatic Stress Response to Cancer Therapies: Evidence for a Positive Co-Operation between TIMP-1, HIF-1α, and miR-210. Frontiers in Pharmacology 3, 134. Review

As co-corresponding author

Liu, Z.*, Wang, J.*, Shi, Y., Yee, B.A., Terrey, M., Zhang, Q., Lee, J.C., Lin, K.I., Wang, AHC., Ackerman, S.L., Yeo, G.W., Cui, H., Yang, X-L. Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery. Nucleic Acids Res . 2023 Sep 22;gkad773

As contributing author

Postdoc at Scripps Research:
Jones, J.A., Wei, N., Cui, H., Shi, Y., Fu, G, Rauniyar, N., Shapiro, R., Morodomi, Y., Berenst, N., Dumitru, C.D., Kanaji, S., Yates, J.R., Kanaji, T., Yang, X.L., 2023. Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”. Cell Rep. 2023 Jun 13;42(6):112632

Istvan E.S., Guerra F., Abraham M., Huang K-S., Rocamora F., Zhao H., Xu L., Pasaje C., Kumpornsin K., Luth M.R., Cui H., Yang T, Diaz S.P., Gomez-Lorenzo M.G., Qahash T., Mittal N., Ottilie S., Niles J., Lee M.C.S, Llinas M., Kato N., Okombo J., Fidock D.A., Schimmel P., Gamo F.J., Goldberg D.E., Elizabeth A Winzeler, E.A., 2023. Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Sci Transl Med, 15(686):eadc9249

Feng, Y., Tang, K., Lai, Q., Liang, J., Feng, M., Zhou, ZW., Cui, H., Du, X., Zhang, H., Sun, L., 2022. The Landscape of Aminoacyl-tRNA Synthetases Involved in Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Front Physiol, eCollection 2021.

Wang, J.*, Vallee, I.*, Dutta, A., Wang, Y., Mo, Z., Liu, Z., Cui, H., Su, A.I., Yang X.L., 2020. Multi-omics analyses of aminoacyl-tRNA synthetases in cancer. Genes 11, 1384 .

Postdoc at Technical University of Munich:
Dall, E., Hollerweger, J.C., Dahms, S.O., Cui, H., Häussermann, K., Brandstetter, H., 2018. Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states. The Journal of Biological Chemistry 293, 13151–13165.

Dubiella, C., Baur, R., Cui, H., Huber, E.M., Groll, M., 2015. Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine. Angewandte Chemie International Edition 54, 15888–15891.

PhD at MRI TUM:
Kobuch, J., Cui, H., Grünwald, B., Saftig, P., Knolle, P.A., Krüger, A., 2015. TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice. Haematologica 100, 1005–1013.

Dubiella, C., Cui, H., Gersch, M., Brouwer, A.J., Sieber, S.A., Krüger, A., Liskamp, R.M.J., Groll, M., 2014. Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site. Angewandte Chemie International Edition 53, 11969–11973.

Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krüger, A., Schmidt, B., Groll, M., 2014. Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif. Angewandte Chemie International Edition 53, 1679–1683.

Undergraduate work

Hoesl, M.G., Larregola, M., Cui, H., Budisa, N., 2010. Azatryptophans as tools to study polarity requirements for folding of green fluorescent protein. Journal of Peptide Science 16, 589–595.

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*Authors contributed equally.